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Medications

Tolvaptan Oral Tablets (Polycystic Kidney Disease)

What is this medicine?

TOLVAPTAN (tol VAP tan) treats certain types of kidney disease.

How should I use this medicine?

Take this drug by mouth with a full glass of water. Take it as directed on the prescription label at the same time every day. You can take it with or without food. If it upsets your stomach, take it with food. Keep taking it unless your health care provider tells you to stop.

Do not take this drug with grapefruit juice.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your health care provider about the use of this drug in children. Special care may be needed.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • confusion

  • dizziness

  • fast, irregular heartbeat

  • feeling faint or lightheaded, falls

  • signs and symptoms of liver injury like dark yellow or brown urine; general ill feeling or flu-like symptoms; light-colored stools; loss of appetite; nausea; right upper belly pain; unusually weak or tired; yellowing of the eyes or skin

  • unusually weak or tired

  • weight loss

Side effects that usually do not require medical attention (report these to your doctor or health care professional if they continue or are bothersome):

  • increased thirst

  • increased urination

What may interact with this medicine?

Do not take this medicine with any of the following medications:

  • ceritinib

  • certain antibiotics like chloramphenicol, clarithromycin, dalfopristin; quinupristin, telithromycin

  • certain antiviral medicines for HIV or AIDS like atazanavir, cobicistat, darunavir, delavirdine, fosamprenavir, indinavir, nelfinavir, ritonavir, saquinavir, tipranavir

  • certain medicines for fungal infection like ketoconazole, itraconazole, posaconazole, voriconazole

  • conivaptan

  • grazoprevir

  • idelalisib

  • mifepristone

  • nefazodone

  • ribociclib

  • tucatinib

This medicine may also interact with the following medications:

  • desmopressin

  • digoxin

  • fluconazole

  • grapefruit juice

  • rifampin

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Where should I keep my medicine?

Keep out of the reach of children and pets.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused drug after the expiration date.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • cannot feel if you are thirsty

  • dehydration

  • liver disease

  • low or high levels of sodium in the blood

  • problems urinating

  • an unusual or allergic reaction to tolvaptan, other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

What should I watch for while using this medicine?

Visit your health care provider for regular checks on your progress. Tell your health care provider if your symptoms do not start to get better or if they get worse.

Check with your health care provider if you have severe diarrhea, nausea, and vomiting, or if you sweat a lot. The loss of too much body fluid may make it dangerous for you to take this drug.

You may need blood work done while you are taking this drug.


NOTE:This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider. Copyright© 2020 Elsevier